Coversyl 10 mg 30 Tablets
Perindopril
Perindopril is an angiotensin converting enzyme (ACE) inhibitor that inhibits the conversion of angiotensin I to angiotensin II by blocking the activity of the converting enzyme. The inhibition of ACE will result in decreased concentrations of Angiotensin II which will then result in decreased vasoconstriction activity because Angiotensin II receptorsare deactivated. It also results in decreased water retention because aldosterone production is terminated.
Indications:
• Hypertension.
• Symptomatic heart failure.
• Prevention of cardiovascular mortality or nonfatal myocardial infarction in patients with stable coronary artery disease.
Points of interest:
• Cough is commonly associated with ACE. An angiotensin-II receptor antagonist (ARB) is recommended to substitute this agent if cough was indicated.
•This medication may cause dizziness. Get up from lying or sitting position gradually to avoid dizziness on standing. Do not drive or operate machinery until you know how it affects you.
• Do not take potassium supplements while using this medication because of risk of potassium overload.
How to use:
As per as direction of doctor.
Active Ingredients:
Perindopril.
Side effects:
• Hypotension.
• Headache.
• Dizziness.
• Cough.
• Hyperkalaemia.
Cautions:
• It may cause a fall in blood pressure, symptomatic hypotension is seen rarely in uncomplicated hypertensive patients. If hypotension occurs, patient should be placed in the supine position and if necessary, should receive IV infusion of sodium chloride (0.9%) solution.
• Additional lowering of systemic blood pressure may occur in patients with congestive heart failure.
• Contraindicated in pregnant women.
• Contraindicated in patients with acute kidney injury.
Interactions:
• Aliskren: the concomitant use of perindopril with aliskiren should be avoided.
• Angiotensin-II receptor antagonists: the risk of hyperkalemia increases when perindopril is given with angiotensin-II receptor antagonists.
• Ciclosporin: the risk of hyperkalemia is increased when perindopril is given with ciclosporin.
• Potassium-sparing diuretics: the risk of severe hyperkalemia (potentially lethal) is increased especially in conjunction with renal impairment when perindopril is given with potassium-sparing diuretics.
• Potassium salts: the risk of severe hyperkalemia is increased when perindopril is given with potassium salts.
Quantity:
30 Tablets
How to store:
Keep at room temperature.
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